84-5601-29　［取扱停止］TRAF2 30ul　543279

特徴

• TNF receptor-associated factor 2 encoded by TRAF2 is a member of the TNF receptor associated factor (TRAF) protein family.
• TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily.
• This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1.
• This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB.
• The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors.
• The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation.
• BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis.
• Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
• Applications:Suitable for use in Western Blot, Immunohistochemistry, and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry (paraffin): 1:100-1:300ELISA: 1:10,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.