GPBAR1 encodes a member of the G protein-coupled receptor (GPCR) superfamily.
This enzyme functions as a cell surface receptor for bile acids.
Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor.
The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids.
Alternative splicing results in multiple transcript variants encoding the same protein.
Applications:Suitable for use in Immunofluorescence and ELISA.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:200-1:1000ELISA: 1:10,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human TGR5.
Isotype：IgG
Calc Applications Abbrev：E IF
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa30-110 of human TGR5 at N-terminal.
