TGIF2 (TGFB induced factor homeobox 2) is a protein coding gene.
Diseases associated with TGIF2 include holoprosencephaly 4.
Among its related pathways are transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and mir34a and TGIF2 in osteoclastogenesis.
The protein encoded by TGIF2 is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes.
TGIF2 is amplified and over-expressed in some ovarian cancers.
Alternative splicing results in multiple transcript variants.
A related pseudogene has been identified on chromosome 1.
Read-through transcription also exists between TGIF2 and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human TGIF2. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to human TGIF2.
