84-5596-91　［取扱停止］TGF Beta 2 100ul　543058

特徴

• TGF Beta 2 encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins.
• Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression.
• The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer.
• The mature peptide may also form heterodimers with other TGF-beta family members.
• Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers.
• A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye.
• Mutations in this gene may be associated with Loeys-Dietz syndrome.
• TGFbeta 2 encodes multiple isoforms that may undergo similar proteolytic processing.
• Applications:Suitable for use in Western Blot, Immunohistochemistry and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry (paraffin): 1:500-1:200ELISA: 1:10,000-1:20,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.