TNXB (tenascin XB) encodes a member of the tenascin family of extracellular matrix glycoproteins.
The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive.
This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome.
TNXB localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.
It is one of four genes in this cluster which have been duplicated.
The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein.
The structure of TNXB is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively.
Multiple transcript variants encoding different isoforms have been found for TNXB.
Applications:Suitable for use in Immunohistochemistry and ELISA.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 1:100-1:300ELISA: 1:10,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human Tenascin-X.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa1730-1810 of human Tenascin-X.
