Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al.
1998 [PubMed 9520462]).
In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation.
TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) TCL1A (T-cell leukemia/lymphoma 1A) is a protein coding gene.
Diseases associated with TCL1A include precursor T-cell acute lymphoblastic leukemia and T-cell leukemia.
Among its related pathways are PI3K-Akt signaling pathway and PI3K/Akt signaling.
An important paralog of TCL1A is MTCP1.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:10,000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human Tcl1.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa30-110 from human Tcl1.
