SOCS3 encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family.
SSI family members are cytokine-inducible negative regulators of cytokine signaling.
The expression of SOCS3 is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma.
The protein encoded by SOCS3 can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase.
Studies of the mouse counterpart of SOCS3 suggested the roles of SOCS3 in the negative regulation of fetal liver hematopoiesis, and placental development.
SOCS3 suppressor of cytokine signaling 3) is a protein coding gene.
Diseases associated with SOCS3 include overnutrition and atopic dermatitis.
Among its related pathways are type II interferon signaling (IFNG) and Adipocytokine signaling pathway.
Applications:Suitable for use in Immunohistochemistry and ELISA.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 1:50-1:200ELISA: 1:10,000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human SOCS-3. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa20-70 from human SOCS-3.
