SMC1B (structural maintenance of chromosomes 1B) is a protein coding gene.
Among its related pathways are Meiosis and Oocyte meiosis.
An important paralog of this gene is SMC1A.
Meiosis-specific component of cohesin complex.
Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment.
Contributes to axial element (AE) formation and the organization of chromatin loops along the AE.
Plays a key role in synapsis, recombination and chromosome movements.
The cohesin complex is required for the cohesion of sister chromatids after DNA replication.
The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped.
At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human SMC1B.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa110-190 from human SMC1B.
