84-5582-56　［取扱停止］SLAF7 30ul　542318

特徴

• SLAMF7 (SLAM family member 7) is a protein coding gene.
• Diseases associated with SLAMF7 include multiple myeloma.
• Among its related pathways are class I MHC mediated antigen processing and presentation and innate immune system.
• Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family.
• SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response.
• Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2.
• Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway.
• Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B.
• Downstream signaling implicates PLCG1, PLCG2 and PI3K.
• In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation.
• However, in the absence of SH2D1B, inhibits NK cell function.
• Acts also inhibitory in T-cells (By similarity).
• May play a role in lymphocyte adhesion.
• In LPS-activated monocytes negatively regulates production of proinflammatory cytokines.
• Isoform 3 does not mediate any NK cell activation.
• Applications:Suitable for use in Western Blot and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.