84-5582-01　［取扱停止］Sin3B 30ul　542290

特徴

• SIN3B (SIN3 Transcription Regulator Family Member B) is a Protein Coding gene.
• Paired amphipathic helix protein Sin3b acts as a transcriptional repressor.
• Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities.
• Interacts with MAD-MAX heterodimers by binding to MAD.
• The heterodimer then represses transcription by tethering SIN3B to DNA.
• Also forms a complex with FOXK1 which represses transcription.
• Among its related pathways are Gene Expression and Metabolism.
• Gene Ontology (GO) annotations related to this gene include chromatin binding and RNA polymerase II transcription corepressor activity.
• An important paralog of this gene is SIN3A.
• Applications:Suitable for use in Western Blot, Immunofluorescence, and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunofluorescence: 1:200-1:1000ELISA: 1:10,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.