84-5581-87 ［取扱停止］SIGIR 100ul 542283
特徴
- SIGIRR (single Ig and TIR domain containing) is a protein coding gene.
- Diseases associated with SIGIRR include perinatal necrotizing enterocolitis.
- Among its related pathways are activated TLR4 signalling and toll-Like receptor signaling pathways.
- Acts as a negative regulator of the toll-like and IL-1R receptor signaling pathways.
- Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4.
- Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
- Applications:Suitable for use in Western Blot and ELISA.
- Other applications not tested.
- Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
- Storage and Stability:May be stored at 4°C for short-term only.
- Aliquot to avoid repeated freezing and thawing.
- Store at -20°C.
- Aliquots are stable for 12 months after receipt.
- For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
- Size：100ul
- Host：rabbit
- Source Antibody：human
- Grade：Affinity Purified
- Purity：Purified by immunoaffinity chromatography.
- Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Specificity：Recognizes endogenous levels of human SIGIR. Species Crossreactivity: mouse and rat
- Isotype：IgG
- Calc Applications Abbrev：E WB
- Calc Crossreactivity：Hu Mo Rt
- Immunogen：Synthetic peptide corresponding to human SIGIR protein.
- Swiss Prot Number：Q6IA17
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