84-5580-79　［取扱停止］Sgo1, phosphorylated (Ser14) 30ul　542230

特徴

• Shugoshin-like 1 encoded by SGO1 is a member of the shugoshin family of proteins.
• This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit.
• Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest.
• Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase.
• An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID: 18331714).
• Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID: 25282101).
• Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence.
• Pseudogenes of this gene have been found on chromosomes 1 and 7.
• Alternative splicing results in multiple transcript variants.
• Applications:Suitable for use in Immunohistochemistry and ELISA.
• Other applications not tested.
• Recommended Dilution:Immmunohistochemistry (paraffin): 1:100-1:300ELISA: 1:5000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.