SIGMAR1 encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines.
The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems.
As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of SIGMAR1 was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor.
Mutations in SIGMAR1 has been associated with juvenile amyotrophic lateral sclerosis 16.
Alternative splicing of SIGMAR1 results in transcript variants encoding distinct isoforms.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human SGMR1. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa90-170 from human SGMR1.
