RGR (retinal G protein coupled receptor) encodes a putative retinal G-protein coupled receptor.
RGR is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family.
Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain.
The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal.
The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells.
The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells.
RGR may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively).
Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications:Suitable for use in Immunohistochemistry, Immunofluorescence, and ELISA.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 1:100-1:300Immunofluorescence: 1:200-1:1000ELISA: 1:5000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human RGR.
Isotype：IgG
Calc Applications Abbrev：E IF IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa140-220 of human RGR.
