TNFRSF11A (TNF receptor superfamily member 11a) is a protein coding gene.
Diseases associated with TNFRSF11A include osteopetrosis, autosomal recessive 7 and osteolysis, familial expansile.
Among its related pathways are Akt Signaling and CDK-mediated phosphorylation and removal of Cdc6.
The protein encoded by TNFRSF11A is a member of the TNF-receptor superfamily.
This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK.
This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells.
This receptor is also an essential mediator for osteoclast and lymph node development.
Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone.
Alternatively spliced transcript variants have been described for this locus.
Applications:Suitable for use in Western Blot, Immunohistochemistry, ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry (paraffin): 1:500-1:200ELISA: 1:10,000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human RANK. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa60-120 from human RANK.
