84-5565-22　［取扱停止］R4RL2 30ul　541444

特徴

• RTN4RL2 (reticulon 4 receptor like 2) is a protein coding gene.
• Among its related pathways are metabolism of proteins and post-translational modification- synthesis of GPI-anchored proteins.
• GO annotations related to this gene include receptor activity.
• An important paralog of this gene is RTN4RL1.
• Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity).
• Plays a functionally redundant role in postnatal brain development.
• Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum.
• Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system.
• Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity).
• Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed: 22325200).
• Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed: 22325200).
• Applications:Suitable for use in Western Blot and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.