Protein tyrosine phosphatase, non-receptor type 13 encoded by PTPN13 is a member of the protein tyrosine phosphatase (PTP) family.
PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
This PTP is a large intracellular protein.
It has a catalytic PTP domain at its C-terminal and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements.
This PTP was found to interact with, and dephosphorylate, Fas receptor and Ikappa Balpha through the PDZ domains.
This suggests it has a role in Fas mediated programmed cell death.
This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways.
Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 1:50-1:300Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human PTN13.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to human PTN13 protein.
