84-5563-01　［取扱停止］PRPF38A 100ul　541330

特徴

• PRPF38A (Pre-mRNA-splicing factor 38A) is a 312aa nuclear protein that is likely required for pre-mRNA splicing.
• There are two isoforms of PRPF38A that are produced as a result of alternative splicing events.
• The gene encoding PRPF38A maps to human chromosome 1, the largest human chromosome which spans about 260 million base pairs and makes up 8% of the human genome.
• There are about 3000 genes on chromosome 1 and considering the great number of genes there are also a large number of diseases associated with chromosome 1.
• Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A.
• When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs.
• The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration.
• The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis.
• Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.
• Applications:Suitable for use in Western Blot, Immunohistochemistry, ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry (paraffin): 1:100-1:300ELISA: 1:20,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.