84-5561-06　［取扱停止］PP2A-B55-beta 30ul　541231

特徴

• The product of PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta) belongs to the phosphatase 2 regulatory subunit B family.
• Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division.
• It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits.
• The B regulatory subunit might modulate substrate selectivity and catalytic activity.
• PPP2R2B encodes a beta isoform of the regulatory subunit B55 subfamily.
• Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements.
• Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene.
• The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 55-78 copies in cases of SCA12.
• Applications:Suitable for use in Western Blot and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:40,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.