Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression.
ZCCHC17 (zinc finger, CCHC domain containing 17), also known as PS1D (putative S1 RNA-binding domain protein), Pnn (Pinin)-interacting nucleolar protein or pNO40, is a 241aa protein that associates with both Pinin and the 60S ribosomal subunit.
Localizing to nucleolus, ZCCHC17 is ubiquitously expressed and has been suggested to play a role in ribosome maturation and biogenesis.
ZCCHC17 contains one CCHC-type zinc finger, a S1 motif domain and exists as two alternatively spliced isoforms that map to human chromosome 1p35.2.
Human chromosome 1 spans 260 million base pairs, contains over 3000 genes, comprises nearly 8% of the human genome and houses a large number of disease-associated genes, including those that are involved in Stickler syndrome, Parkinson's disease, Gaucher disease and Usher syndrome.
Applications:Suitable for use in Immunohistochemistry and ELISA.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 1:100-1:300ELISA: 1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human pNO40. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to aa30-110 of human pNO40.
