84-5557-83　［取扱停止］PKC beta, phosphorylated (Ser661) 30ul　541064

特徴

• Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol.
• PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.
• PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters.
• Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells.
• The protein encoded by PRKCB (protein kinase C beta) is one of the PKC family members.
• This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption.
• Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress.
• Alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Applications:Suitable for use in Western Blot, Immunohistochemistry, and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry (paraffin): 1:100-1:300ELISA: 1:20,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.