PICALM (phosphatidylinositol binding clathrin assembly protein) is a protein coding gene.
Diseases associated with PICALM include Leukemia, acute myeloid and precursor T-cell acute lymphoblastic leukemia.
Among its related pathways are clathrin derived vesicle budding and clathrin-mediated endocytosis.
PICALM encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly.
The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage.
The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human PICAL.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa290-370 from human PICAL.
