PHOX2B (pairedlLike homeobox 2b) is a protein coding gene.
Diseases associated with PHOX2B include central hypoventilation syndrome, congenital and neuroblastoma 2.
Among its related pathways are neural crest differentiation and sudden infant death syndrome (SIDS) susceptibility pathways.
The DNA-associated protein encoded by PHOX2B is a member of the paired family of homeobox proteins localized to the nucleus.
The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype.
PHOX2B product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element.
Expansion of a 20aa polyalanine tract in this protein by aa5-13 has been associated with congenital central hypoventilation syndrome.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human PHX2B. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to aa140-220 from human PHX2B.
