PHOX2A (paired like homeobox 2a) is a protein coding gene.
Diseases associated with PHOX2A include fibrosis Of extraocular muscles, congenital, 2 and Tukel syndrome.
Among its related pathways are sudden infant death syndrome (SIDS) susceptibility pathways.
The protein encoded by PHOX2A contains a paired-like homeodomain most similar to that of the drosophila aristaless gene product.
The encoded protein plays a central role in development of the autonomic nervous system.
It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype.
The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human PHX2A. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa210-290 from human PHX2A.
