PF-4 encodes a member of the CXC chemokine family.
This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation.
PF-4is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function.
The protein also exhibits antimicrobial activity against Plasmodium falciparum.
(PF4 platelet factor 4) is a protein coding gene.
Diseases associated with PF4 include Erythromelalgia and Thrombocytopenia.
Among its related pathways are response to elevated platelet cytosolic Ca2+ and Akt signaling.
Applications:Suitable for use in Immunohistochemistry, ELISA.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 1:50-1:200ELISA: 1:10,000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human PF-4. Species Crossreactivity: rat
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu Rt
Immunogen：Synthetic peptide corresponding to aa51-100 from human PF-4.
