The protein encoded by PPBP is a platelet-derived growth factor that belongs to the CXC chemokine family.
This growth factor is a potent chemoattractant and activator of neutrophils.
It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan.
It also stimulates the formation and secretion of plasminogen activator by synovial cells.
The protein also is an antimicrobial protein with bactericidal and antifungal activity.
PPBP (Pro-Platelet Basic Protein) is a Protein Coding gene.
Diseases associated with PPBP include Erythromelalgia and Essential Thrombocythemia.
Among its related pathways are Response to elevated platelet cytosolic Ca2+ and p70S6K Signaling.
Applications:Suitable for use in Immunohistochemistry, ELISA.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 1:50-1:200ELISA: 1:10,000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human PBP.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa71-120 from human PBP.
