Pan3 (PAB-dependent poly(A)-specific ribonuclease subunit 3) is a 741aa cytoplasmic protein belonging to the protein kinase superfamily.
Containing a protein kinase domain, pan3 is a component of the pan nuclease complex and recruits polyadenylate-binding protein, which in turn stimulates Pan2 nuclease activity.
It is suggested that pan3 may have a functional role in cytoplasmic mRNA decay.
Pan3 exists as three isoforms produced by alternative splicing and the gene encoding pan3 is located on human chromosome 13.
chromosome 13 houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome.
Trisomy 13, also known as Patau syndrome, is deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:10,000ELISA: 1:10,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous myristoylated protein. Species Crossreactivity: ALL
