RPS6KB1 encodes a member of the ribosomal S6 kinase family of serine/threonine kinases.
Ribosomal protein S6 kinase B1 responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation.
Activity of RPS6KB1 has been associated with human cancer.
Alternatively spliced transcript variants have been observed.
The use of alternative translation start sites results in isoforms with longer or shorter N-terminal which may differ in their subcellular localizations.
There are two pseudogenes for RPS6KB1 on chromosome 17.
Applications:Suitable for use in Western Blot, Immunohistochemistry, and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry (paraffin): 1:100-1:300ELISA: 1:40,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human p70 S6 kinase alpha. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human p70 S6 kinase alpha around the non-phosphorylation site of T444.
