Cyclin dependent kinase inhibitor 2C encoded by CDKN2C is a member of the INK4 family of cyclin-dependent kinase inhibitors.
Cyclin dependent kinase inhibitor 2C has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression.
Ectopic expression of CDKN2C was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function.
Studies in the knockout mice suggested the roles of CDKN2C in regulating spermatogenesis, as well as in suppressing tumorigenesis.
Two alternatively spliced transcript variants of CDKN2C, which encode an identical protein, have been reported.
Applications:Suitable for use in Western Blot, Immunohistochemistry, and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry (paraffin): 1:100-1:300ELISA: 1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human p18. Species Crossreactivity: mouse and monkey
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Mk Mo
Immunogen：Synthetic peptide corresponding to aa80-160 of human p18 at C-terminal.
