The protein encoded by RBL1 (RB transcriptional corepressor like 1) is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene.
The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle.
Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein.
In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters.
Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor.
Two transcript variants encoding different isoforms have been found for RBL1.
Applications:Suitable for use in Immunofluorescence, ELISA.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:200-1:1000ELISA: 1:5000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human p107. Species Crossreactivity: Mouse
Isotype：IgG
Calc Applications Abbrev：E IF
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to human p107 around the non-phosphorylation site of T369.
