TNF receptor superfamily member 11b encoded by TNFRSF11B is a member of the TNF-receptor superfamily.
TNF receptor superfamily member 11b is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption.
TNF receptor superfamily member 11b specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development.
Studies of the mouse counterpart also suggest that TNF receptor superfamily member 11b and its ligand play a role in lymph-node organogenesis and vascular calcification.
Alternatively spliced transcript variants of TNFRSF11B have been reported, but their full length nature has not been determined.
Applications:Suitable for use in Western Blot, Immunofluorescence, Immunohistochemistry, and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunofluorescence: 1:200-1:1000Immunohistochemistry (paraffin): 1:100-1:300ELISA: 1:10,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human OPG at ~55kD. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E IF IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to aa10-90 of human OPG at N-terminal.
