The product of NFATC1 is a component of the nuclear factor of activated T cells DNA-binding transcription complex.
This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component.
Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response.
The product of NFATC1 is an inducible nuclear component.
It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
Different isoforms of this protein may regulate inducible expression of different cytokine genes.
Applications:Suitable for use in Immunohistochemistry and ELISA.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 1:100-1:300ELISA: 1:10,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human NFATc1 (phospho Ser294). Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to human NFATc1 around the phosphorylation site of S294.
