IQCB1 encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein.
IQ calmodulin-binding motif-containing protein 1 has a central coiled-coil region and two calmodulin-binding IQ domains.
It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells.
IQ calmodulin-binding motif-containing protein 1 is thought to play a role in ciliary function.
Defects in this gene result in Senior-Loken syndrome type 5.
Alternative splicing results in multiple transcript variants.
A pseudogene of this gene is found on chromosome 6.
Applications:Suitable for use in Western Blot, Immunohistochemistry, and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry (paraffin): 1:100-1:300ELISA: 1:40,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human Nephrocystin-5.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa400-480 of human Nephrocystin-5.
