84-5524-63　［取扱停止］Myomesin-1 30ul　539365

特徴

• The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs.
• The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190kD (myomesin 1) and 165kD (myomesin 2).
• This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains.
• Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II.
• The two proteins share 50% sequence identity in this repeat-containing region.
• The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band.
• The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins.
• Alternatively spliced transcript variants encoding different isoforms have been identified.
• Applications:Suitable for use in Immunohistochemistry and ELISA.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry (paraffin): 1:100-1:300ELISA: 1:40,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.