84-5520-76　［取扱停止］MRGX1 100ul　539151

特徴

• MRGPRX1 (MAS related GPR family member X1) is a protein coding gene.
• GO annotations related to this gene include G-protein coupled receptor activity.
• An important paralog of this gene is MRGPRX4.
• rphan receptor.
• Probably involved in the function of nociceptive neurons.
• May regulate nociceptor function and/or development, including the sensation or modulation of pain.
• Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22) (PubMed: 26582731).
• BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells.
• G(alpha)q proteins are involved in the calcium-signaling pathway.
• Activated by the antimalarial drug, chloroquine.
• May mediate chloroquine-induced itch, in a histamine-independent manner.
• Applications:Suitable for use in Western Blot, Immunofluorescence, and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunofluorescence: 1:200-1:1000ELISA: 1:5000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.