MFGE8 encodes a preproprotein that is proteolytically processed to form multiple protein products.
The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells.
This protein has also been implicated in wound healing, autoimmune disease, and cancer.
Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA).
Alternative splicing results in multiple transcript variants.
MFGE8 (milk fat globule-EGF factor 8 protein) is a protein coding gene.
Diseases associated with MFGE8 include opisthorchiasis and anal paget's disease.
Among its related pathways are integrins in angiogenesis and activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human MFGM.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to human MFGM protein.
