84-5514-71　［取扱停止］MDM2, phosphorylated (Ser186/S188) 30ul　538842

特徴

• MDM2 encodes a nuclear-localized E3 ubiquitin ligase.
• The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation.
• MDM2 is itself transcriptionally-regulated by p53.
• Overexpression or amplification of this locus is detected in a variety of different cancers.
• There is a pseudogene for this gene on chromosome 2.
• Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
• Applications:Suitable for use in Immunofluorescence and ELISA.
• Other applications not tested.
• Recommended Dilution:Immunofluorescence: 1:200-1:1000ELISA: 1:20,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.