The protein encoded by MAX is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors.
It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc.
Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis.
The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation.
Mutations of this gene have been reported to be associated with hereditary pheochromocytoma.
A pseudogene of this gene is located on the long arm of chromosome 7.
Alternative splicing results in multiple transcript variants.
Applications:Suitable for use in Immunohistochemistry and ELISA.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 1:100-1:300ELISA: 1:5000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human Max (phospho Ser2). Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human Max around the phosphorylation site of S2.
