MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5) encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase.
Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response.
This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response.
Two alternatively spliced transcript variants encoding the same protein have been described for MAP4K5.
MAP4K5 is a protein coding gene.
Diseases associated with MAP4K5 include dysgraphia and writing disorder.
Among its related pathways are TGF-Beta pathway and angiopoietin like protein 8 regulatory pathway.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human M4K5. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to aa300-380 from human M4K5.
