Lymphotoxin beta is a type II membrane protein of the TNF family.
It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation.
The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.
G.
1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor.
The minor complex is lymphotoxin-alpha 2/beta 1.
LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue.
Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha.
Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications:Suitable for use in Western Blot, Immunofluorescence, and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunofluorescence: 1:200-1:1000ELISA: 1:10,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human LT-beta. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E IF WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to aa150-230 of human LT-beta at C-terminal.
