LRBA (LPS responsive beige-like anchor protein) is a protein coding gene.
Diseases associated with LRBA include Immunodeficiency, common variable, 8, with autoimmunity and lrba-related common variable immune deficiency.
The protein encoded by LRBA is a member of the WDL-BEACH-WD (WBW) gene family.
Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS).
The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules.
Defects in LRBA are associated with the disorder common variable immunodeficiency-8 with autoimmunity.
Two transcript variants encoding different isoforms have been found for LRBA.
Applications:Suitable for use in Immunohistochemistry (paraffin).
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 1:50-1:300Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human LRBA. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to aa1970-2050 from human LRBA.
