KCNA1 (potassium voltage-gated channel subfamily A member 1) encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Ddosophila shaker channel.
The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD).
The functional channel is a homotetramer.
The N-terminal of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels.
The C-terminal of the channel is complexed to a PDZ domain protein that is responsible for channel targeting.
Mutations in KCNA1 have been associated with myokymia with periodic ataxia (AEMK).
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:1000-1:2000Immunohistochemistry (paraffin): 1:100-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes Kv1.1 potassium channel. Species Crossreactivity: human, mouse and rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to Kv1.1 potassium channel.
