The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70kD and 80kD.
The complex functions as a single-stranded DNA-dependent ATP-dependent helicase.
The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination.
High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
XRCC6 (X-Ray Repair Cross Complementing 6) is a Protein Coding gene.
Diseases associated with XRCC6 include Lupus Erythematosus and Systemic Lupus Erythematosus.
Among its related pathways are DNA Damage and Cytosolic sensors of pathogen-associated DNA.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:10,000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human Ku-70 when Acetyl occurs at Lys317. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa317 of human Ku-70 (Acetyl Lys317).
