OPRK1 encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family.
It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids.
Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release.
This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids.
Variations in OPRK1 have also been associated with alcohol dependence and opiate addiction.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminal extended isoform via the use of an alternative in-frame translation termination codon.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human KOR-1. Species Crossreactivity: mouse, rat, and monkey
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mk Mo Rt
Immunogen：Synthetic peptide corresponding to aa290-370 of human KOR-1 at C-terminal.
