Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses.
The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel.
The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels.
It may function in fluid and pH balance regulation.
Alternatively spliced transcript variants have been found for this gene.
[provided by RefSeq, Apr 2014]KCNJ16 (Potassium Voltage-Gated Channel Subfamily J Member 16) is a Protein Coding gene.
Diseases associated with KCNJ16 include sesame syndrome and body dysmorphic disorder.
Among its related pathways are Transmission across Chemical Synapses and Inwardly rectifying K+ channels.
GO annotations related to this gene include inward rectifier potassium channel activity.
An important paralog of this gene is KCNJ3.
nward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.
Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.
The inward rectification is mainly due to the blockage of outward current by internal magnesium.
KCNJ16 may be involved in the regulation of fluid and pH balance.
In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed: 24561201).
Applications:Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry (paraffin): 1:100-1:300Immunofluorescence: 1:200-1:1000ELISA: 1:10,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of KIR5.1. Species Crossreactivity: human and rat
Isotype：IgG
Calc Applications Abbrev：E IF IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to mouse KIR5.1 around the non-phosphorylation site of S416.
