KDM5B encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases.
The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3.
This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells.
This protein may also play a role in genome stability and DNA repair.
Alternate splicing results in multiple transcript variants.
KDM5B (lysine demethylase 5B) is a protein coding gene.
Diseases associated with KDM5B include ascending colon cancer and autosomal dominant Non-syndromic intellectual disability.
Among its related pathways are chromatin organization and activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human KDM5B. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to human KDM5B protein.
