KDM4D (lysine demethylase 4D) is a protein coding gene.
Among its related pathways are chromatin organization and activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
GO annotations related to this gene include dioxygenase activity and histone demethylase activity (H3-K9 specific).
An important paralog of this gene is KDM4F.
Histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code.
Does not demethylate histone H3 Lys-4, H3 Lys-27, H3 Lys-36 nor H4 Lys-20.
Demethylates both di- and trimethylated H3 Lys-9 residue, while it has no activity on monomethylated residues.
Demethylation of Lys residue generates formaldehyde and succinate.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human KDM4D.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa400-480 from the internal region of human KDM4D.
