KAT6B (lysine acetyltransferase 6B) is a protein coding gene.
Diseases associated with KAT6B include Genitopatellar syndrome and Sbbyss syndrome.
Among its related pathways are chromatin organization.
The protein encoded by KAT6B is a histone acetyltransferase and component of the MOZ/MORF protein complex.
In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end.
This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development.
Mutations have been found in patients with genitopatellar syndrome.
A translocation of KAT6B and the CREBBP gene results in acute myeloid leukemias.
Three transcript variants encoding different isoforms have been found for KAT6B.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human KAT6B. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to aa1170-1250 from the internal region of human KAT6B.
