84-5500-93　［取扱停止］ITLN1 30ul　538123

特徴

• ITLN1 (Intelectin 1) is a protein coding gene.
• Diseases associated with ITLN1 include obesity and diabetes mellitus, Noninsulin-dependent.
• Among its related pathways are common cytokine receptor gamma-chain family signaling pathways and innate immune system.
• GO annotations related to this gene include carbohydrate binding.
• An important paralog of this gene is ITLN2.
• Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed: 11313366, PubMed: 26148048).
• Binds to microbial glycans that contain N-terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed: 26148048).
• Binds to glycans from Gram-positive and Gram-negative bacteria, including K.
• neumoniae, S.
• neumoniae, Y.
• estis, P.
• irabilis and P.
• ulgaris (PubMed: 26148048).
• Does not bind human glycans (PubMed: 26148048).
• Probably plays a role in the defense system against microorganisms (Probable).
• May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed: 16531507).
• Increases AKT phosphorylation in the absence and presence of insulin (PubMed: 16531507).
• May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed: 11747454, PubMed: 23921499).
• Applications:Suitable for use in Western Blot and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.