The product of ITGA5 belongs to the integrin alpha chain family.
Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling.
The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit.
This subunit associates with the beta 1 subunit to form a fibronectin receptor.
This integrin may promote tumor invasion, and higher expression of ITGA5 may be correlated with shorter survival time in lung cancer patients.
Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of fragment of activated human Integrin α5 LC protein resulting from cleavage adjacent to E895.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa850-930 of human Integrin alpha5 LC at C-terminal.
